1. Who Needs Differential Pressure Gauges in GMP Cleanrooms?

In GMP-compliant manufacturing facilities, maintaining pressure differentials between cleanroom zones is a mandatory requirement to control airflow and prevent cross-contamination. A differential pressure gauge is a commonly used device that continuously measures and displays pressure differences in a clear and visual manner.

Areas That Require Pressure Monitoring:

  • Airlock rooms: Connect clean and less-clean areas. Positive pressure is required to ensure airflow moves from clean → less clean.
  • Weighing rooms: High risk of airborne active ingredient particles; requires negative pressure to protect the external environment.
  • Manufacturing, filling, and packaging areas: Must maintain strict cleanliness levels, often with a cascading pressure system.

Without continuous pressure monitoring, airflow may reverse-causing contamination between cleanroom zones.

VCR provides Differential Pressure Gauges for GMP clean rooms

The Role of Differential Pressure Gauges in HVAC Systems:

  • Monitor one-way airflow: Ensure air moves from clean → less clean → dirty zones.
  • Provide timely alerts: Some gauges include alarms when pressure exceeds safe thresholds.
  • Comply with GMP/ISO 14644: Helps QA teams validate and audit environmental conditions.

Common Users of Differential Pressure Gauges:

  • HVAC engineers - responsible for designing and installing controlled environments.
  • QA/QC professionals - in charge of environmental monitoring and GMP compliance.
  • Investors or plant managers - who make equipment purchase decisions aligned with regulatory needs.

See more: The Structure of Differential Pressure Gauge Cleanroom

2. Common Types of Differential Pressure Gauges for GMP Applications

Depending on the level of control and budget, GMP facilities typically use one of three main types of differential pressure gauges:

Gauge Type

Features

Advantages

Limitations

Mechanical (dual needle)

Operates without electricity

Low cost, durable, easy to read, simple installation

No alarm feature, cannot store data

Digital

Digital display with sensors

High accuracy, integrated alarm and signal output

Higher cost, requires power supply

Integrated Sensor - BMS

Connects to BMS or PLC

Centralized monitoring, easy to manage multiple rooms

Requires advanced installation and system integration

Selection Suggestions Based on GMP Application:

  • Airlocks and auxiliary rooms: Mechanical gauges may suffice if data logging isn't required.
  • Weighing and filling rooms: Digital gauges with alarms are ideal to quickly detect risks of cross-contamination.
  • Large-scale factories with automated systems: Use BMS-integrated pressure sensors for centralized monitoring.

Note: Some HVAC consultants recommend installing both mechanical and digital gauges in critical areas to ensure redundancy and manual data verification when needed.

See more: What is A Differential Pressure Gauge Cleanroom

3. How to Identify a Reliable Differential Pressure Gauge Supplier

Not all cleanroom equipment vendors fully understand GMP requirements. For a critical device like a differential pressure gauge, choosing a reliable supplier is essential to ensure system stability and regulatory compliance.

4 Key Qualities of a Trusted Supplier:

  1. Proven Experience with GMP Facilities
  • Supplied equipment to pharmaceutical, cosmetic, and food plants compliant with EU-GMP, WHO-GMP, HACCP.
  • Understands stringent requirements in cleanroom zoning, environmental control, and pressure validation.

Common types of differential pressure gauges for GMP

  1. Complete Documentation Provided
  • CO - Certificate of Origin: Verifies product origin.
  • CQ - Certificate of Quality: Manufacturer’s quality certification.
  • Technical documents included: datasheets, drawings, and installation guides.
  1. Full Technical Support Services
  • GMP-compliant installation: On-site support for wall or duct mounting according to cleanroom layout.
  • Scheduled calibration: Keeps pressure readings accurate over time.
  • Quick maintenance and replacement services: Minimizes downtime during operations.
  1. Transparent Website with Application-Based Guidance
  • Equipment categorized by industry, zone, and technical requirements.
  • Smart recommendations for choosing the right product: weighing rooms, airlocks, sterile areas, etc.
  • Easy access to specifications, downloadable documents, and quote requests.

A professional supplier doesn’t just sell devices-they support you throughout the entire equipment lifecycle: from selection to installation, calibration, and after-sales service.

See more: Latest price list of Differential pressure gauge used in Cosmetic factory

4. Why Choose Vietnam Cleanroom Equipment (VCR)?

Among hundreds of cleanroom equipment suppliers on the market, VCR stands out not only for product quality but also for deep expertise in GMP standards and strong technical support capabilities.

Trusted by EU-GMP and WHO-GMP Certified Facilities

  • VCR is a trusted partner of major pharmaceutical manufacturers in Vietnam and across Southeast Asia.
  • Successfully delivered hundreds of differential pressure gauge systems for GMP-compliant weighing rooms, airlocks, and sterile filling areas.
  • Readily provides CO-CQ, technical drawings, and installation instructions to support GMP audits.

GMP standard differential pressure gauge

Full Range of Models and Accessories to Meet Every Need

  • Supplies all three major types: mechanical gauges, digital gauges, and BMS-integrated sensors.
  • Accessories available in stock: pressure ports, mounting flanges, protective enclosures - enabling quick installation.
  • Always in stock, suitable for urgent projects or facility expansions.

End-to-End Support from Experienced Engineers

  • Technical consultation to help select the most suitable device: what pressure differential is required for each room? Which gauge type is optimal?
  • On-site installation service when needed.
  • Periodic calibration and maintenance to ensure long-term GMP compliance.

Easy Product Selection via a 16-Website Ecosystem

  • VCR operates a network of 16 specialized websites by industry and product category, making it easy to:
    • Research in-depth by sector: pharmaceuticals, food, cosmetics, electronics.
    • Choose the right device based on specific cleanroom areas: airlocks, weighing rooms, sterile zones.

With VCR, you're not just buying equipment - you're gaining a full support system with GMP expertise from start to finish.

See more: Selecting the Perfect Differential Pressure Gauge for Your Cleanroom

5. Frequently Asked Questions About Differential Pressure Gauges in GMP Cleanrooms

1. Is it mandatory to use differential pressure gauges in GMP cleanrooms?

→ Yes. According to GMP standards, areas with different cleanliness classifications (e.g., weighing rooms, airlocks, processing rooms) must monitor and record pressure differentials to ensure unidirectional airflow from clean → less clean zones and prevent cross-contamination.
Lack of pressure monitoring is considered a serious non-compliance issue during GMP audits.

Differential pressure gauge for GMP clean room

2. What type of pressure gauge is best for a pharmaceutical weighing room?

→ Digital gauges with pressure alarm functions are the best option for weighing rooms, which require continuous monitoring, high accuracy, and immediate response to pressure changes.
Some facilities also integrate digital gauges with BMS/PLC systems to store data for audit and validation purposes.

3. How often should differential pressure gauges be calibrated?

→ At least once a year, or every six months depending on the facility's internal SOPs and risk classification of the monitored area.
Calibration ensures accurate readings and prevents false alarms or undetected pressure issues.
VCR offers on-site calibration services with GMP-compliant documentation.

6. Contact Us - Choose the Right Differential Pressure Gauge for Your GMP Cleanroom

Are you designing, upgrading, or preparing your facility for a GMP inspection?
Don’t let pressure control issues affect your entire production line.

Let Vietnam Cleanroom Equipment (VCR) help you select the right differential pressure gauge-tailored to your cleanroom layout, GMP requirements, and budget.

  • Free consultation based on your cleanroom layout
  • Fast delivery with on-site technical support
  • CO, CQ, and full technical documentation available upon request

Hotline: 090.123.9008

Email: [email protected]

Website: https://donghochenhap.com/

Diep VCR